Ampicillin Stability in a Portable Elastomeric Infusion Pump: A Step Forward in Outpatient Parenteral Antimicrobial Therapy

نویسندگان

چکیده

Outpatient parenteral antimicrobial therapy (OPAT) with continuous infusion pumps is postulated as a very promising solution to treat complicated infections, such endocarditis or osteomyelitis, that require patients stay in hospital during extended periods of time, thus reducing their quality life and increasing the risk complications. However, stability studies drugs elastomeric devices are scarce, which limits use OPAT. Therefore, we evaluated ampicillin sodium chloride 0.9% at two different concentrations, 50 15 mg/mL, an pump when stored refrigerator subsequently real-life conditions temperatures, 25 32 °C, without cooling device. The mg/mL stable for up 72 h under refrigeration, allowing subsequent dosing °C 24 device, but its concentration drops below 90% after 8 h. In contrast, only remains first administration room temperature not possible, even system. Our data support AMP suitable OPAT if volume rate tailored dosage needs treatments.

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ژورنال

عنوان ژورنال: Pharmaceutics

سال: 2023

ISSN: ['1999-4923']

DOI: https://doi.org/10.3390/pharmaceutics15082099